Phagosome proteomes open the way to a better understanding of phagosome function
نویسندگان
چکیده
منابع مشابه
Contributions of proteomics to understanding phagosome maturation
In metazoans macrophage cells use phagocytosis, the process of engulfing large particles, to control the spread of pathogens in the body, to clear dead or dying cells, and to aid in tissue remodelling, while the same process is also used by unicellular eukaryotes to ingest food. Phagocytosing cells essentially swallow the particles, trapping them in vacuoles called phagosomes that go through a ...
متن کاملThe Phagosome Proteome: Insight into Phagosome Functions
Phagosomes are key organelles for the innate ability of macrophages to participate in tissue remodeling, clear apoptotic cells, and restrict the spread of intracellular pathogens. To understand the functions of phagosomes, we initiated the systematic identification of their proteins. Using a proteomic approach, we identified . 140 proteins associated with latex bead– containing phagosomes. Amon...
متن کاملMore than one way to skin a phagosome
In This Issue In This Issue More than one way to skin a phagosome hagosome studies have rested on a major assumption: that in a given cell, all phagosomes with the same cargo mature alike. On page 185, Henry et al. test this assumption, and find it wanting. Using ratiometric fluorescence microscopy, the authors followed the maturation of individual macrophage phago-somes containing IgG-opsonize...
متن کاملThe Phagosome Proteome
Phagosomes are key organelles for the innate ability of macrophages to participate in tissue remodeling, clear apoptotic cells, and restrict the spread of intracellular pathogens. To understand the functions of phagosomes, we initiated the systematic identification of their proteins. Using a proteomic approach, we identified >140 proteins associated with latex bead-containing phagosomes. Among ...
متن کاملA Drosophila Model to Image Phagosome Maturation
Phagocytosis involves the internalization of extracellular material by invagination of the plasma membrane to form intracellular vesicles called phagosomes, which have functions that include pathogen degradation. The degradative properties of phagosomes are thought to be conferred by sequential fusion with endosomes and lysosomes; however, this maturation process has not been studied in vivo. W...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2007
ISSN: 1465-6906
DOI: 10.1186/gb-2007-8-3-207